Acquired pure megakaryocytic aplasia successfully treated with cyclosporine
Acquired pure megakaryocytic aplasia is a rare hematological disorder characterized by thrombocytopenia with absent or markedly reduced megakaryocytes in the bone marrow. We report a case of a 25-year-old male diagnosed as acquired pure megakaryocytic aplasia. Treatment with prednisone and intravenous immunoglobulin failed, but he was successfully treated with cyclosporine, with complete remission after 90 days and normal platelet count maintained thereafter.

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Authors: Halima El Omri, Firyal Ibrahim, Ruba Yasin Taha, Riham Hassan Negm, Aisha Al Khinji, Mohammed Yassin, Ibrahim Al Hijji, Hanadi El Ayoubi, Hussein Baden

Keywords: Kazanılmış amegakaryositik trombositopeni, steroidler, siklosporin

• Year: 2010
• Number: 4
• Referance No: 58661

---

• 

  Figure 1. A. Peripheral smear showing severe thrombocytopenia (Wright stain X1000). B: Bone marrow biopsy shows mixed cellular hemopoietic cells with absent megakaryocytes before treatment (H&E stain X400)
• 

  Figure 2. A. Peripheral smear after treatment with cyclosporine (after 3 months) showing normalization of the platelet count (Wright stain X1000). B: Bone marrow biopsy shows active marrow with adequate number of megakaryocytes (H&E X400)
• 

  Figure 3. Clinical course with treatment given and changes in platelet count